Association of Standardized Uptake Values of Primary Breast Cancer on [18F]FDG PET/CT With Immunohistochemistry and Molecular Subtypes

Background: The prognostic factors for breast cancer include pretreatment staging, nodal and distant metastasis, hormone receptor status, ki67 index, molecular subtype. For adequate treatment, [18F]FDG PET/CT is now being used to prognosticate the course response of treatment in patients. Our study aims find association between metabolic activity primary tumors as SUV uptake such ER/PgR/Her2neu subtypes, labeling nodal/distant metastasis. Methods: A retrospective observational at our tertiary care institute included 228 patients from March 2017 April 2021. Pretreatment imaging was done. immunohistochemical analysis performed on a biopsy/surgical specimen determine subtype cancer. Further, statistical findings with immunohistochemistry thus, subtypes cancers. Results: Significantly higher max seen ER-negative (Mean SUVmax-11.6; P-value=0.002), PgR negative SUVmax-11.1; p value-0.0005), triple-negative status SUVmax-13.7; P-value=0.004) high Ki67 index (P-value=<0.01). Further Luminal max:6.0±5.5 & Median max:3.9±3.6) B max: 8.9±4.9 max:7.6±4.0) showed lower compared Her2neu 9.4±5.5 max:8.6±6.2) TNBC 13.7±12.4 max:10.0±7.6) subtypes. However, only weak correlation found axillary spread p-value – 0.02) no significant Her2 SUVmax-9.7; value-0.178) metastasis (P-value=0.26). Conclusion: values different can be Mean or uptake. owing data skewing practical scenarios, we suggest use median interquartile range predicting imaging: 3.9 (IQR 3.6); ­­– 7.6 4.0); Enriched 8.6 - 6.2); Triple-negative 10.0 7.6).